Basic Information
VIS ID
TVIS10002889
Fusion event
HBV-chr11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73382226/73671181 (Hg38)
End
73382226/73671181 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/887589; hsa-let-7a-2/Downstream/728056;
Nearest TSS
ENST00000527297/Upstream/8828; ENST00000538624/Downstream/51168;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/9594, chr11-CpG: 112/Downstream/89049
Nearby gene
PLEKHB1(-8362) ; RAB6A(+4457) ;
Upstream sequence
gtaatcctagcactttgggaggttaaagcaggtgtactgcttgagcccaggagtccaagaccagcccaagcaacatagtgagaccccatctctacccaaa
Downstream sequence
atacaaaaatcagccacgcatggtggcacgtgccttggtcccagctacttgggaggctgaggtggtaagattgcttgagcctgggagggagaggttgcag
Target sequence
GGTTAGTTTTCTTTACAAATGAAAACATAAAATATAAAGGATATAAGCTAAGGAATGCAAAATCACAATGGAAAGAGATTCAGGGAACTTCTTGTAAATATCTCCTGCAAGAGGTATCTGTGGGATCCACCCAGATCTCCATAACCTCTGTTACAGGCAGGGTCTTCAACCTGACTTAGCCCATATGTGCGGAAAGGAAAAGGGCCTGCGTTTCCAATCATGCTGTCAGAAAAAGGAGACTGTGGAAAAATTTTC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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