Basic Information
VIS ID
TVIS10002932
Fusion event
HBV-chr8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
7277561/7420039 (Hg38)
End
7277561/7420039 (Hg38)
Location type
Promoter;downstream
Target gene
DEFB103A ; DEFB103B ; DEFB4B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-3674/Upstream/674795; hsa-mir-10400/Downstream/668902;
Nearest TSS
ENST00000518652/Upstream/3176; ENST00000335510/Downstream/10309;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/64671, chr8-CpG: 20/Downstream/108630
Upstream sequence
caggctgaggcaggagaatcaggcagggaggttgcagtgagccgagatggcagcagtacagtccagcttcggctccgcatgagagggagaccgtggggat
Downstream sequence
GCTGTGCTGAAGGTTGGTGGGACAAGTGATGTTGAAGTGAATGAAGAGAAAGACAGAGTTATAGGTGCACTTAATGCTACAAGAGCTGCTGTTGAAGAAG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate