Basic Information
VIS ID
TVIS10002979
Fusion event
HBV-LHX8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
75650434/75184749 (Hg38)
End
75650434/75184749 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
LHX8
Nearest miRNA
hsa-mir-101-1/Upstream/4117033; hsa-mir-11399/Downstream/1875394;
Nearest TSS
ENST00000473358/Upstream/25461; ENST00000473018/Downstream/426335;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/47625, chr1-CpG: 34/Downstream/430020
Nearby gene
LHX8(-23216) ; SLC44A5(+17382) ;
Upstream sequence
ccacaccaaaaagttagaaagatctcaaattcacaacttaacatcgcagctaaaagaactaaagaggcaagagcaaccccaaagctagcagaaaagaaat
Downstream sequence
aacacaaatcagagctgaactggagaccaagacacaaaagaccattcaaaagatgaataaatccagcagctgtttttttttttttggaaaattaataaaa
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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