Basic Information
VIS ID
TVIS10003095
Fusion event
HBV-chr9 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
21960812/21960813 (Hg38)
End
21960812/21960813 (Hg38)
Location type
Promoter;downstream
Fragile sites / regions
FRA9C
Target gene
CDKN2A ; CDKN2A-DT
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-let-7g-5p ; hsa-mir-125b-5p ; hsa-mir-492 ; hsa-mir-10b-5p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-455-3p ; hsa-mir-423-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-320a
Nearest miRNA
hsa-mir-101-2/Upstream/448628; hsa-let-7a-1/Downstream/6902813;
Nearest TSS
ENST00000422679/Upstream/30423; ENST00000441769/Downstream/6116;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/157831, chr9-CpG: 51/Downstream/4284
Nearest cancer related gene
CDKN2A(TSG, No orient, 0)
Upstream sequence
ttttctttttttttttttggttccactgggttattttttcaaaagatctgtctttaagttgaaaaattatttctctgttgttgaagctctcaattgtatt
Downstream sequence
GGTTGACAGGTAGAAGGATCCTAAAATTTAATTCCTGGGCTGCTAACTTCAAATCTCATCTGTATCAACAGTTTTCTCACTTAAGTCATTAACATCGaaa
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate