Basic Information
VIS ID
TVIS10003417
Fusion event
HBV-RCC1L integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
74496509/75080698 (Hg38)
End
74496509/75080698 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA7J
Target gene
RCC1L
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-185-3p ; hsa-mir-503-5p ; hsa-mir-186-5p ; hsa-mir-29a-3p ; hsa-mir-26a-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-10525/Upstream/484672; hsa-mir-10399/Downstream/834499;
Nearest TSS
ENST00000635602/Upstream/6470; ENST00000613786/Downstream/11875;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/6604, chr7-CpG: 91/Downstream/11646
Upstream sequence
ttagctcttacatttagatttatgatccactgtaatttttatgtatgttgtgaggaaacaacttcattattttgtatgtggatatctaattgtcccagaa
Downstream sequence
tcctgcctcagcctcccgagtagctgggaccacaggtatgcaccaccacgcctagctaattttttttttttttttttttttgtattttcagtagagacgg
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate