Basic Information
VIS ID
TVIS10003536
Fusion event
HBV-chr1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr1
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
94715287/94249731 (Hg38)
End
94715287/94249731 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
ARHGAP29 ; ARHGAP29-AS1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-124-3p ; hsa-mir-204-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-410-3p ; hsa-mir-3163 ; hsa-mir-3936 ; hsa-mir-6782-5p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-4284 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-150-5p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-6814-5p ; hsa-mir-6890-3p ; hsa-mir-4681 ; hsa-mir-4786-3p ; hsa-mir-5692a ; hsa-mir-3190-5p ; hsa-mir-3926 ; hsa-mir-4684-5p ; hsa-mir-490-3p ; hsa-mir-548c-3p ; hsa-mir-548s ; hsa-mir-593-3p ; hsa-mir-6818-3p ; hsa-mir-6895-3p
Nearest miRNA
hsa-mir-101-1/Upstream/402820; hsa-mir-11399/Downstream/293971;
Nearest TSS
ENST00000473358/Upstream/1865; ENST00000468860/Downstream/25337;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1770, chr1-CpG: 101/Downstream/168238
Nearby gene
ARHGAP29(-11980) ; ABCD3(+168646) ;
Nearest cancer related gene
ARHGAP29(TSG, No orient, 0)
Upstream sequence
gtcccagctcttgggaggcggaggcaagagaatcgcttgaacccaggaggcagaggttgtggtgagctgagattgtgccattgcactctagcctggtcaa
Downstream sequence
caagagtgaaactccatctcaaaaaaaaaaaaagaaagaaaaTTAGTCATCCTATTTGACATCATATTGTACATAGGATACTATTCTTGTGGCACTTATG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate