Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10003781
Fusion event
HBV-PPP2R5C integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr14
Cytoband
q32.31
Reference genome
End
102341634/101875297 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-31-3p ; hsa-mir-135b-5p ; hsa-mir-15a-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-1277-5p ; hsa-mir-3190-3p ; hsa-mir-3607-5p ; hsa-mir-3611 ; hsa-mir-4524a-5p ; hsa-mir-5011-5p ; hsa-mir-4524b-5p ; hsa-mir-6505-5p ; hsa-mir-6833-5p ; hsa-mir-6838-5p ; hsa-mir-7114-5p ; hsa-mir-29c-5p ; hsa-mir-4680-5p ; hsa-mir-134-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-3664-5p ; hsa-mir-548ao-3p ; hsa-mir-193b-3p ; hsa-mir-193a-3p
Nearest miRNA
hsa-mir-1185-1/Upstream/314875; hsa-mir-12121/Downstream/664347;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/93355, chr14-CpG: 17/Downstream/16253
Nearest cancer related gene
PPP2R5C(TSG, No orient, 0)
Upstream sequence
AAAGCAGCTCTTGCTGTGGAGGAAGCGCGAGGTAGATTTGTGGGAAGAAGGCTCTGCTCTCCCTTACCTCTCTTCACTGCCGAGCACTCATTGTGTGCCA
Downstream sequence
GGGCCAGCAGGAAGATATTAAACCAAGGACTTCCCGGCCACCCAGTCATACTTGAGATAAATATTCCAAAGAAAATGTACAGCATCATAGAAGAGCTTAA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.