IGHMBP2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10003843
Fusion event
HBV-IGHMBP2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
68684724/68917256 (Hg38)
End
68684724/68917256 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11H ; FRA11A
Target gene
IGHMBP2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-877-3p ; hsa-mir-18a-3p ; hsa-mir-18a-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10392/Upstream/872299; hsa-let-7a-2/Downstream/165920;
Nearest TSS
ENST00000527297/Upstream/13330; ENST00000568742/Downstream/8940;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/13103, chr11-CpG: 68/Downstream/88072
Upstream sequence
ttagtagagacagcgtttcactgtgttggccaggctggtctcgatttcctgagctcgtgatctgcctgcctcgggctcccaaagtgctgggattacaggc
Downstream sequence
atgagccaccgcgcctgaccAGTTCCATCTTTTTGAGATATTAAAGTAAGTTGAGGTTTTGATTATGGGTTGAAAAAATTTTTTTTAATCTCTTGAAAAA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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