Basic Information
VIS ID
TVIS10003902
Fusion event
HBV-chr12 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
114940555/114502750 (Hg38)
End
114940555/114502750 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA12E ; FRA12C
Nearest miRNA
hsa-let-7i/Upstream/1211142; hsa-mir-1178/Downstream/1645810;
Nearest TSS
ENST00000382841/Upstream/93996; ENST00000547819/Downstream/119011;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/53976, chr12-CpG: 94/Downstream/162132
Nearby gene
TBX5-AS1(-89918) ; TBX3(+167504) ;
Nearest cancer related gene
TBX3(OG, +167504) ;
Upstream sequence
AGGGAGATTGGTGATCAGTCTTCAAACTTGGTCTAGTGCAAGCGACCCACTGGGTCCCTGTGCCCCCATCTCCCAGGACCCACAGGATCCCATTGCCTCA
Downstream sequence
GAAAAATGACATTTCTTTGGTCTCTGGATAGAAACAGACTAAGGGACTGAAGTGGTCCATGCCCTGTTGGTGATGGCTCCCTTTTTCATGACATCTATTC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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