Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004080
Fusion event
HBV-CCNE1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
Start
End
30302082/29811175 (Hg38)
Location type
Promoter
Target gene
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b
Nearest miRNA
hsa-mir-10395/Upstream/9411821; hsa-let-7e/Downstream/5311525;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/86488, chr19-CpG: 137/Downstream/213
Nearest cancer related gene
CCNE1(OG, No orient, 0)
Upstream sequence
tctcggcctcccacaatgctgggattaaaggcgtgagccaccgcgcccggccTCAACTGGAAGGCTTTAAGTGAGAGATGGGGTGCAAGGGAATCCCAGA
Downstream sequence
GTCAGAAAGGTCTTCAGAGAGCCAGGAAGGGCTTGCGGGGGAGGGGCGCATATGGAAGGGGCGCATGGAAGGAACTCACAGATTCCTTGAATGAATGAAT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.