Basic Information
VIS ID
TVIS10004087
Fusion event
HBV-DESI2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
244857804/244694502 (Hg38)
End
244857804/244694502 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
DESI2
miRNAs that regulate target gene
hsa-mir-497-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1348247; hsa-mir-3124/Downstream/2507465;
Nearest TSS
ENST00000473358/Upstream/40751; ENST00000632004/Downstream/36460;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/40724, chr1-CpG: 109/Downstream/35637
Upstream sequence
CTATTGCATTACTCATCGTTGAAATTCTTAAGATGAACTGGATGCTGCAGCAGCTGCCCTCTTGGGTTTAGGTGGTGTTCCTTCACGGAATCTGTGCCTG
Downstream sequence
AATCTGCGGTCTACAATTTTTAGGTGCCTCATTCGACCAGTCCCAGTGGTATTTTGTCTTTTAGCCTTGGCACTGCCGTTATACTTTCTCTTGCGCTTGG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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