Basic Information
VIS ID
TVIS10004096
Fusion event
HBV-NECTIN3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr3
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
110908047/111189200 (Hg38)
End
110908047/111189200 (Hg38)
Location type
Intronic
Target gene
NECTIN3
miRNAs that regulate target gene
hsa-mir-3163 ; hsa-mir-100-3p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548n
Nearest miRNA
hsa-let-7g/Upstream/1586303; hsa-mir-12124/Downstream/923601;
Nearest TSS
ENST00000440867/Upstream/114305; ENST00000485506/Downstream/3151;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/116646, chr3-CpG: 21/Downstream/485280
Upstream sequence
ATAATGGCACTTGTTTCAAGCCTTGAAAGATAAAAATGTTAATAAACAGAGAAAAAAAAAAGAGAATTCAGATTGAAAAACAACATGGATAATAGCACAG
Downstream sequence
CTAGAAGTGTCAGACTTAGAAATTAAGTCACACTATTAGACATGAGGGACTGCTGAAGAAAATGGTATGAGCAGACTGTGGCATGTCTGTCAGAGGTTCC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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