VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10004132

Fusion event

HBV-FN1 integration

Validated

No

Detection method

HIVID

Data source

Curated

Sample type

Nontumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

27703150

Virus Sequence

Virus name

HBV

Reference genome

AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1

Host Sequence

Chromosome

chr2

Cytoband

q35

Reference genome

GRCh37/hg19

Start

216285340/215420617 (Hg38)

End

216285340/215420617 (Hg38)

Location type

Intronic

Target gene

FN1

miRNAs that regulate target gene

hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-1-3p ; hsa-let-7g-5p ; hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-140-3p

Nearest miRNA

hsa-mir-10b/Upstream/1662458; hsa-mir-1244-1/Downstream/2479896;

Nearest TSS

ENST00000437798/Upstream/10667; ENST00000412951/Downstream/653;

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/108208, chr2-CpG: 43/Downstream/14927

Upstream sequence

CAGTATTAGAGAGAAGACTTTGCAAAGTTCTTTGCAAGCAACTGATCAAAGTCTGGAGCCAACTTCAGTCATGTGATTTCACATAGCTTTTCTTATCTGA

Downstream sequence

AACTTGCTAACCATTCCCCCTGTGCAAACTCATCTAGGGAAATAGGGCTACTCACCGACGGGATCACACTTCCACCTGCCCCGACCCTGACCGAAGCATG

Reference

Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.