Basic Information
VIS ID
TVIS10004175
Fusion event
HBV-MFSD4A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
205549775/205580647 (Hg38)
End
205549775/205580647 (Hg38)
Location type
Intronic
Target gene
MFSD4A
miRNAs that regulate target gene
hsa-mir-665 ; hsa-mir-887-5p ; hsa-mir-510-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4738-3p ; hsa-mir-3192-5p ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p
Nearest miRNA
hsa-mir-101-1/Upstream/132249; hsa-mir-1182/Downstream/894156;
Nearest TSS
ENST00000473358/Upstream/1049; ENST00000471425/Downstream/11390;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/11209, chr1-CpG: 33/Downstream/11314
Upstream sequence
GGGGCTGGGGGAGGGGGCTCAGTGTGGGTCCTCTGGACCGGAGGCCAGGCCACCACTTCCCCGGGCTGAAGACTGACCCCCACCCCCACCCGCCACCTCT
Downstream sequence
CCTCTGTCCCCAGGTGCTCCATTTCTTCGTGGGCTTTGGTGCTCTGCTGAGCCCCCTTATTGCTGACCCTTTCCTGTCTGAGGCCAACTGCTTGCCTGCC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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