Basic Information
VIS ID
TVIS10004344
Fusion event
HBV-chr21 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43068825/41648665 (Hg38)
End
43068825/41648665 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/481036; hsa-mir-5692b/Downstream/98107;
Nearest TSS
ENST00000624081/Upstream/67346; ENST00000413718/Downstream/30516;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/139918, chr21-CpG: 32/Downstream/40524
Nearby gene
TMPRSS2(-188740) ; LINC00111(+30637) ;
Nearest cancer related gene
TMPRSS2(OG, -188740) ;
Upstream sequence
TACAACACTAAAGTTGTGTGGACTGCAAGACCAATGGGCTGGAAACCCAAAGCAAATGCATTCCAAGGGAGGGTGATGTCTCCGTGGATGTGTGAAGCTG
Downstream sequence
AAGATAAGGCACAGCAGCAGGGTGGCAGGAAGAGCAGAGAAGTGTTCATGGCTCAAGATGGCCAGTGACCAGCTGGGCCCCGGGGGAGGCAGAGGGAAGC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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