Basic Information
VIS ID
TVIS10004347
Fusion event
HBV-KANSL3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
97268548/96602811 (Hg38)
End
97268548/96602811 (Hg38)
Location type
Exonic
Fragile sites / regions
FRA2S
Target gene
KANSL3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-877-3p ; hsa-mir-93-3p ; hsa-mir-484 ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-4301 ; hsa-mir-4705 ; hsa-mir-6500-3p ; hsa-mir-141-5p ; hsa-mir-196a-3p ; hsa-mir-7106-3p ; hsa-mir-3128 ; hsa-mir-150-5p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-1273g-3p ; hsa-mir-21-5p ; hsa-mir-3200-5p ; hsa-mir-4539 ; hsa-mir-4754 ; hsa-mir-590-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/7790357; hsa-mir-10b/Downstream/195467;
Nearest TSS
ENST00000437798/Upstream/900; ENST00000505256/Downstream/4023;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/52323, chr2-CpG: 54/Downstream/35391
Upstream sequence
CTCCCTACACCTGCCCAGCCCAGCAGATGGCAGATGTGCACCTGTGGGGCTGGTCCTGGGGAGGGATTTGCTGGAAGGCCAGAGGTCTTGCTGCTGATAT
Downstream sequence
CCTGCAAGCTGAAGCTGAGGCCTTGGAGGAGGCTGCTGGCTGATGTGGCCCCTAAGAGAGGACATAGCAGGAATCAGTAGAGACTCAATCACTTGCACTA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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