SPRED2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004474
Fusion event
HBV-SPRED2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr2
Cytoband
p14
Reference genome
GRCh37/hg19
Start
65543447/65316313 (Hg38)
End
65543447/65316313 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
SPRED2
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-6822-5p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4715-5p ; hsa-mir-1914-5p ; hsa-mir-6776-3p ; hsa-mir-31-5p ; hsa-mir-487a-3p
Nearest miRNA
hsa-mir-1301/Upstream/790748; hsa-mir-10b/Downstream/1041936;
Nearest TSS
ENST00000437798/Upstream/88137; ENST00000629214/Downstream/18460;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2136, chr2-CpG: 223/Downstream/114321
Upstream sequence
TCTGAGCTCCAGCTACATCCGCCTGAGCAAGACTGGGCCTGTAGCCTGTAAGGCTGGGGGCTCGAGCCAAGTGTGCAGCATTCCTTAGTCCTGATTGTGG
Downstream sequence
CTCTGGGCTTCCACACAAAGCTGGGAGGCCCTTTGGACAGAGGAATGCAGGACGCAGTGTAGCCCCCTGGGTGAGAACAGGCTTGGATTTGAATCTCGTT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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