Basic Information
VIS ID
TVIS10004476
Fusion event
HBV-THEM6 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
143814100/142732682 (Hg38)
End
143814100/142732682 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
THEM6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-877-5p ; hsa-mir-4451 ; hsa-mir-6809-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-765 ; hsa-mir-6499-3p ; hsa-mir-4708-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-17-3p ; hsa-mir-194-3p ; hsa-mir-3922-5p ; hsa-mir-1296-3p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-4695-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418
Nearest miRNA
hsa-mir-1204/Upstream/556264; hsa-mir-10400/Downstream/1000401;
Nearest TSS
ENST00000518652/Upstream/4959; ENST00000518798/Downstream/1848;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/4790, chr8-CpG: 81/Downstream/6368
Upstream sequence
catgaagcttattgtctagcaaggaaagcagacactaattatatcattgcaaataaataaaatagtcacgttttgattcttttatgaaggaataaaatca
Downstream sequence
tcctttaccttaggttgctggccagtttcttttttttttttttttctgcattgctgagagtccgggtttattcgtcacaccaggtgggtctcaatttctc
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate