Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004536
Fusion event
HBV-VAV2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr9
Cytoband
q34.2
Reference genome
End
136656030/133790908 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-320a ; hsa-let-7a-5p ; hsa-mir-148a-3p ; hsa-mir-218-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-6081 ; hsa-mir-6827-5p ; hsa-mir-6124 ; hsa-mir-873-5p ; hsa-mir-3192-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-331-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6165 ; hsa-mir-4524b-3p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-1273d ; hsa-mir-4493 ; hsa-mir-4753-5p
Nearest miRNA
hsa-let-7a-1/Upstream/738849; hsa-mir-126/Downstream/588503;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/89134, chr9-CpG: 15/Downstream/3081
Nearest cancer related gene
VAV2(OG, No orient, 0)
Upstream sequence
GCACGGATGTTCCTAGAAAAATTGAGACTGCTCTGAGGATTTCCAGTGCCAAGTCCTGCATCAGGGAGGGCTCATTTTGTAGCTCTGACATAGGATGGAT
Downstream sequence
caccaggggtaattttgccacccaaaggaccctctggtaatgtccagaggcatatctggttggcattacttgagggggtgggggtgctactggtgtctgg
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.