Basic Information
VIS ID
TVIS10004603
Fusion event
HBV-chr1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
145468535/145966553 (Hg38)
End
145468535/145966553 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
NBPF10 ; NBPF20 ; POLR3GL
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-216b-3p ; hsa-mir-4798-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3942-3p ; hsa-mir-7154-5p ; hsa-mir-549a ; hsa-mir-1250-3p ; hsa-mir-8060 ; hsa-mir-1324 ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-1277-5p ; hsa-mir-6516-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-mir-101-1/Upstream/115908; hsa-mir-1182/Downstream/2367926;
Nearest TSS
ENST00000473358/Upstream/1837; ENST00000612371/Downstream/27663;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1705, chr1-CpG: 18/Downstream/30037
Upstream sequence
accatgcctggctaattttttttgtagttttagtagagatggggtttctccatgttggtcaggctggtcttgtactcctgacttcgtgatccacccgcct
Downstream sequence
tggcctcacaaagtgctgggattacaggcatgagccatcacgcccggccTCttttttttttttttttttttgagacaggttcttgctctgtcgcttaggc
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate