Basic Information
VIS ID
TVIS10004622
Fusion event
HBV-chr8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
42240302/42382784 (Hg38)
End
42240302/42382784 (Hg38)
Location type
Promoter
Target gene
DKK4 ; VDAC3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-186-3p ; hsa-mir-196a-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-124-1/Upstream/722276; hsa-mir-10400/Downstream/513413;
Nearest TSS
ENST00000518652/Upstream/5552; ENST00000519072/Downstream/8840;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/44077, chr8-CpG: 91/Downstream/8753
Upstream sequence
AAATTACAGGTGGGAAAATGAGTTGAAATTAAATATTTGTAAACAAAATAAACTTCTCCCCAATTCATTTGTCAATTTTTTTTCCTTTATGATCACATTC
Downstream sequence
TGACTAAGCTTAGAGGAAATGAAATTTCTCAAAAAAAAATTTCCAGAGGTCCCAGTTTCTGCACTGATTCCACTCTTTGGGTAAAAATTGCAGACTCGTG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate