Fusion event
HBV-chr3 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGG| |ACTGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACG
End
100422313/100703469 (Hg38)
Nearest miRNA
hsa-let-7g/Upstream/739071; hsa-mir-12124/Downstream/2820564;
Nearest cancer related gene
Upstream sequence
TAGAGTATAAACTTATATGCCATTAATATTTACATGAATGAAAAAAATTAAAGTTTTTACTTAGATCTATTTTGAGCATACTCAATAACATTTGTGTTAA
Downstream sequence
GAAATTGTTCTTAAATTAACTTAAAATATTTTCTCATCTAAGAAACACATGAATATGTTTTCCTTAAAAGAAAAACAAAAAACCCAACAACAAAGAACAA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).