Basic Information
VIS ID
TVIS10004641
Fusion event
HBV-MEF2C-AS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1735
Orient
+
Integrated sequence
TCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGA| |GGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCC
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
88432442/89136625 (Hg38)
End
88432442/89136625 (Hg38)
Orient
+
Location type
Intronic
Target gene
MEF2C-AS1
Nearest miRNA
hsa-mir-10397/Upstream/469686; hsa-mir-103a-1/Downstream/879996;
Nearest TSS
ENST00000502646/Upstream/170750; ENST00000508742/Downstream/282182;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/246853, chr5-CpG: 17/Downstream/1272901
Junction sequence
G
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate