MTUS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004643
Fusion event
HBV-MTUS2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1752
Orient
+
Integrated sequence
CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCA
Host Sequence
Chromosome
chr13
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
29623309/29049172 (Hg38)
End
29623309/29049172 (Hg38)
Orient
+
Location type
Intron
Target gene
MTUS2
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-124-3p ; hsa-mir-4761-3p
Nearest miRNA
hsa-mir-2276/Upstream/4886668; hsa-mir-1267/Downstream/10614862;
Nearest TSS
ENST00000623511/Upstream/228824; ENST00000255289/Downstream/22812;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/228411, chr13-CpG: 31/Downstream/290577
Upstream sequence
ACCCTCTCTTTGCATATTGTCAGGTTACTATTCAGAATGGTGCCATTTAGGCTGAAAAAGCAAATGGCAGATTTTGCAACTCTTTGGCCAGTGAGAGTCT
Downstream sequence
AAGTATGGAAGACAAGGTGAATTTAAATGTTATTAATGGATTCTTCTGAAATCTATTCACAAGGACATCCTTTTGTTTGCTTGCTATTTTTATGAAGAGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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