Basic Information
VIS ID
TVIS10004650
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1793
Orient
+
Integrated sequence
CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA| |TTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
163740588/163771351 (Hg38)
End
163740588/163771351 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1428711; hsa-mir-1182/Downstream/2136570;
Nearest TSS
ENST00000473358/Upstream/431096; ENST00000485769/Downstream/784233;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/348041, chr1-CpG: 34/Downstream/549927
Upstream sequence
ATCCTTCTAGGTAGGCAATAGCGTTATCAAGAAGGGCTCCACACATGGGCTGCTTCTCCCTTCCTTTCTCTGATGAGTTGAAAGGTATTTTCAGGGGAAG
Downstream sequence
ATGTGTGGGTCTATTACCAGGAGAAAGGGCAAGGCATGAGCAATTGCAAGTTGTGACTTTCCAGGTCCCATCAACTTGACGATTGCAACTCCACCAAGGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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