Basic Information
VIS ID
TVIS10004652
Fusion event
HBV-LOC440040 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1761
Orient
+
Integrated sequence
ACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAA| |AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACT
Host Sequence
Chromosome
chr11
Cytoband
p11.12
Reference genome
GRCh37/hg19
Start
49604162/49582610 (Hg38)
End
49604162/49582610 (Hg38)
Orient
+
Location type
Intron
Target gene
LOC440040
Nearest miRNA
hsa-mir-129-2/Upstream/1485752; hsa-let-7a-2/Downstream/7161263;
Nearest TSS
ENST00000527297/Upstream/373940; ENST00000555099/Downstream/369781;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/23883, chr11-CpG: 25/Downstream/235118
Upstream sequence
ACAGATAGCTCTGGAAGGAGTGTTTAGAGGGGCATTCCCTCCTCTTCCCTTTCCAGAAGGAACAGCCTATGGACTCAGTAAATAATTTCTAAGAGAGTTA
Downstream sequence
TTATTGCCTCTTTCAGAGAAAAATATAGAGCTTGCTGACATATCCACATGTGGTTTGGGCAGTGTTTCTTCTATATTCAGATTCATTTCTGATGATACAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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