Basic Information
VIS ID
TVIS10004657
Fusion event
HBV-LOC107984660 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1826
Orient
+
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
23452754/22983545 (Hg38)
End
23452754/22983545 (Hg38)
Orient
+
Location type
Promoter
Target gene
LOC107984660
Nearest miRNA
hsa-mir-4707/Upstream/26516; hsa-mir-1185-1/Downstream/405051;
Nearest TSS
ENST00000550708/Upstream/647; ENST00000408907/Downstream/19224;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/580, chr14-CpG: 55/Downstream/23168
Upstream sequence
TAGGACAGTTAGAGGGATAGACACCCCCTGGTGTTGGGAAATGAGATTTTTCTCATTTCAGGTGACTGTGGAGATCGAAGGCCTGGTTTTAGGGCTAGCG
Downstream sequence
AACACCTTCTCCCTTTGGTTTTGGTCCACAGAAGACTGGTGATACAGAGTAAGTATTAAGAGGAAGAAAAGAAATGCCGTGTAGAGGAAATTGCAAATGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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