FHIT _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004663
Fusion event
HBV-FHIT integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2472
Orient
-
Integrated sequence
GAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGG| |TGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTAT
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
60411416/60425683 (Hg38)
End
60411416/60425683 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/4573089; hsa-mir-12124/Downstream/192122;
Nearest TSS
ENST00000440867/Upstream/344843; ENST00000475527/Downstream/825701;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1375465, chr3-CpG: 48/Downstream/825249
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Junction sequence
AA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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