Basic Information
VIS ID
TVIS10004664
Fusion event
HBV-chr3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1610
Orient
+
Integrated sequence
GGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATG| |GAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCA
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
152744174/153026385 (Hg38)
End
152744174/153026385 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA3D
Nearest miRNA
hsa-let-7g/Upstream/1460390; hsa-mir-1224/Downstream/6256261;
Nearest TSS
ENST00000440867/Upstream/191692; ENST00000323534/Downstream/135390;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/190462, chr3-CpG: 228/Downstream/134094
Upstream sequence
tcaaaggtagagagtgttacagatggtgcaaatatcaagaagtgaaattaaagcagttgagttaaatttgtacagtgttatccttgtttgtactaaattc
Downstream sequence
GTTTTAATTGAAAAATACATATTCACAACGTAGCTCTAAAGATAAATTAATTGTGGCTGATATTTGCTCAATCATATCATTTTTCTGTATCGATATTAAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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