Fusion event
HBV-TERT integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCT| |AATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCT
End
1275390/1275275 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-4635/Upstream/212301; hsa-mir-10397/Downstream/34035;
Nearest cancer related gene
Upstream sequence
cttatatatatgtatgcatatatatatatatatatcacaatttctttatcttctcattgattgatggccatttgggctggttccatatttttgcaattgc
Downstream sequence
aggcaagagaattgcttgaactcaggaagcacaggttgcagtgagccaagatcacgccaaaccactccagcctgggcaaaaaagagcgagactctgttat
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).