Basic Information
VIS ID
TVIS10004667
Fusion event
HBV-LOC107986841 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1568
Orient
+
Integrated sequence
GCCGTTTGGGGCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCT| |GCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTG
Host Sequence
Chromosome
chr7
Cytoband
q31.33
Reference genome
GRCh37/hg19
Start
123931153/124291099 (Hg38)
End
123931153/124291099 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986841
Nearest miRNA
hsa-mir-10525/Upstream/7270780; hsa-mir-10399/Downstream/2766989;
Nearest TSS
ENST00000635602/Upstream/3555; ENST00000497598/Downstream/43195;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/257462, chr7-CpG: 19/Downstream/473021
Upstream sequence
GAAAAGAGCAGCACATAATTGCAGAATATTAATAAATGGTTAAAACTTTGCATTGGCTGGGATTATAGTGATTTTTTACCTTCTGCTACCTAGCAAACTT
Downstream sequence
cagacacatgccaccattcctggctaatttttttgtaattttaatagagacggggtttgaaatggccgggcaaactcctgacctcaggtgatgtgcccac
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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