hsa-mir-497-3p _LIHC.png
DPP6 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004668
Fusion event
HBV-DPP6 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2881
Orient
+
Integrated sequence
AGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCA| |TGGGGACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTT
Host Sequence
Chromosome
chr7
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
154631149/154839439 (Hg38)
End
154631149/154839439 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA7I
Target gene
DPP6
miRNAs that regulate target gene
hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-4668-5p ; hsa-mir-3153 ; hsa-mir-513b-3p ; hsa-mir-1276 ; hsa-mir-497-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-511-5p ; hsa-mir-6830-3p
Nearest miRNA
hsa-mir-10399/Upstream/3405800; hsa-mir-153-2/Downstream/2734897;
Nearest TSS
ENST00000635602/Upstream/35547; ENST00000488512/Downstream/26044;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/44813, chr7-CpG: 19/Downstream/53253
Upstream sequence
AAAAGAGCAGCACATAATTGCAGAATATTAATAAATGGTTAAAACTTTGCATTGGCTGGGATTATAGTGATTTTTTACCTTCTGCTACCTAGCAAACTTT
Downstream sequence
tgctggcgttaccacttacagttctgtgcctgtttattcctctgtgaaatggggacgtagcgcctcttgcctggggctacgttaaggaatgaatgagttt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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