hsa-mir-3202 _LIHC.png
hsa-mir-6798-3p _LIHC.png
UBE4B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004673
Fusion event
HBV-UBE4B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2341
Orient
-
Integrated sequence
TGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACT| |GTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAAT
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
10191186/10131128 (Hg38)
End
10191186/10131128 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA1A
Target gene
UBE4B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-3p ; hsa-mir-92a-3p ; hsa-mir-6885-3p ; hsa-mir-3926 ; hsa-mir-1251-3p ; hsa-mir-4753-5p ; hsa-mir-9-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-6870-5p ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4668-5p ; hsa-mir-3202 ; hsa-mir-3148 ; hsa-mir-3179 ; hsa-mir-873-5p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6783-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-2681-5p ; hsa-mir-607 ; hsa-mir-29b-2-5p ; hsa-mir-580-3p ; hsa-mir-3671 ; hsa-mir-584-5p ; hsa-mir-6798-3p ; hsa-mir-186-3p ; hsa-mir-4762-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-12136/Upstream/163670; hsa-mir-101-1/Downstream/1898030;
Nearest TSS
ENST00000473358/Upstream/2789; ENST00000488228/Downstream/27226;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/97782, chr1-CpG: 156/Downstream/78829
Nearest cancer related gene
UBE4B(TSG, No orient, 0)
Junction sequence
CAAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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