Basic Information
VIS ID
TVIS10004674
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1933
Orient
-
Integrated sequence
CCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCT| |TCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
77139845/76674160 (Hg38)
End
77139845/76674160 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/5606444; hsa-mir-11399/Downstream/385983;
Nearest TSS
ENST00000473358/Upstream/37283; ENST00000496845/Downstream/105107;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/876942, chr1-CpG: 112/Downstream/193266
Upstream sequence
aggaacacactggaatcaggaagaaaagccctgtcccactgcgcccagtgcccactattgacaaagtgaaacatcaggccatctggcaaagaaaaagata
Downstream sequence
ttcagagggctcattgaggatggactttgaaagagcaaataatgaaggatAGGGCATGTAACAGTCCAACTGATAATAGTCACAGGGAATTTAGTCTGTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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