Basic Information
VIS ID
TVIS10004675
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1818
Orient
+
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
77139866/76674181 (Hg38)
End
77139866/76674181 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/5606465; hsa-mir-11399/Downstream/385962;
Nearest TSS
ENST00000473358/Upstream/37304; ENST00000496845/Downstream/105086;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/876963, chr1-CpG: 112/Downstream/193245
Upstream sequence
agaaaagccctgtcccactgcgcccagtgcccactattgacaaagtgaaacatcaggccatctggcaaagaaaaagatattcagagggctcattgaggat
Downstream sequence
ggactttgaaagagcaaataatgaaggatAGGGCATGTAACAGTCCAACTGATAATAGTCACAGGGAATTTAGTCTGTTCACAACGTTAATAGTTTTTAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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