Basic Information
VIS ID
TVIS10004678
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1721
Orient
+
Integrated sequence
GAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTG| |TTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACT
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
195045940/195076810 (Hg38)
End
195045940/195076810 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/1940227; hsa-mir-1182/Downstream/1505603;
Nearest TSS
ENST00000473358/Upstream/725867; ENST00000496761/Downstream/984263;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1954716, chr1-CpG: 24/Downstream/1531768
Upstream sequence
CCAGGTACTAAAGGCATTTTAAAAAGTAATTCAATAATTATAATTACACATACTGACTAATTTGCTAAGTTGTATTTCCTCTGCCTCTGTAAGTCCACTT
Downstream sequence
TTTAATGCCAGTAATATAAATACCAATACTGAGAAACTGAAATGTTGTTGAAGTAAATTTTATGCAACATGTGCATTTAATTGCACATGATAGCAAATTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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