Basic Information
VIS ID
TVIS10004681
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1822
Orient
+
Integrated sequence
TTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
7850010/7828463 (Hg38)
End
7850010/7828463 (Hg38)
Orient
+
Location type
Promoter
Nearest miRNA
hsa-mir-210/Upstream/593626; hsa-let-7a-2/Downstream/1261849;
Nearest TSS
ENST00000527297/Upstream/2491; ENST00000640290/Downstream/2377;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/154009, chr11-CpG: 130/Downstream/190399
Nearby gene
OR5P3(-2491) ;
Upstream sequence
TTGGATACTTGAAAATAACCTTTCTTAGCTCCAGCTGAATAGAGATGGCATTCTGAGAGAGAGAGTACAGAAGATAATACACACAATTGTCTAACATACA
Downstream sequence
TTAGTTGCTACAATTTAATTGCTGAATAGCAGAAGGGAGGGTGAAAGCTAATCCCAAAGTTGTGAAGATTGTGAGGAAGGGGTAATAGGTAAACAACTCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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