Basic Information
VIS ID
TVIS10004682
Fusion event
HBV-LOC105369489 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2425
Orient
-
Integrated sequence
ACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGA| |TCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAG
Host Sequence
Chromosome
chr11
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
110890454/111019730 (Hg38)
End
110890454/111019730 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369489
Nearest miRNA
hsa-mir-10392/Upstream/7169750; hsa-let-7a-2/Downstream/328027;
Nearest TSS
ENST00000527297/Upstream/306541; ENST00000635886/Downstream/70638;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/306570, chr11-CpG: 114/Downstream/278849
Upstream sequence
AATTGTAACGAAGAACTGCATGTCACAGGGTGACCATGCGCTCTGTGGCTTCCCTGAATAGACATCAATGATACTTGCTGCCCTCTCCTCCACCGAGATG
Downstream sequence
TCTCCTGTGGGGAGACAGAAGGGGCACTAGCTAAAGATCTTCTCTTTCTCCAGCCTCTCTCCAGTTCAAGTGGCCTGAGGAATTGTAAACTTTTATAAAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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