Fusion event
HBV-CCDC57 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
End
80062089/82104213 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10226/Upstream/410344; hsa-mir-4525/Downstream/132455;
Upstream sequence
TAATCTGAGGTCAACCCAGTAACTGGTGTGTAAAAACGCTCTTGGCCTCCACCACTCTCTGCCCCGCCTTCTCGCCTGACCTGTTTTGCCGAGCCTGGCC
Downstream sequence
GGGATTTCTCTTTCTGCGTTGGGCTGACTGGGCCGCAGGGAAACCATGTGGACACACAGTTTGCCGGGCACAGCGTGAGGAACGCGCCTCTTGGGTCCTG
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).