WDFY1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004687
Fusion event
HBV-WDFY1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1702
Orient
+
Integrated sequence
GTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGC| |ATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGT
Host Sequence
Chromosome
chr2
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
224774901/223910184 (Hg38)
End
224774901/223910184 (Hg38)
Orient
-
Location type
Intron
Target gene
WDFY1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-1301-3p ; hsa-mir-3911 ; hsa-mir-4800-5p ; hsa-mir-3138 ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-2115-5p ; hsa-mir-2355-5p ; hsa-mir-3613-3p ; hsa-mir-3977 ; hsa-mir-516a-3p ; hsa-mir-516b-3p ; hsa-mir-5195-5p ; hsa-mir-7162-5p
Nearest miRNA
hsa-mir-10b/Upstream/4003619; hsa-mir-1244-1/Downstream/1100277;
Nearest TSS
ENST00000437798/Upstream/10908; ENST00000258383/Downstream/35151;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/72111, chr2-CpG: 131/Downstream/34022
Upstream sequence
TGGAAACTCTTCCCTGGCTCTCTGCCTGGCTGGCTCTGTgacaaagatgccaaaaaacttaaatgggggaaaaaaaatagtcttttaaacaattggtgct
Downstream sequence
gggataactggatgtccacatacagaagaataaatgtggaacccctccctgataccactataggaattaacttacaataaatcaaagatctaaatgtaaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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