Basic Information
VIS ID
TVIS10004691
Fusion event
HBV-chr7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2739
Orient
-
Integrated sequence
CCTGCTAGGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTA| |GGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGA
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
80723367/81094051 (Hg38)
End
80723367/81094051 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/5178782; hsa-mir-10399/Downstream/11109964;
Nearest TSS
ENST00000635602/Upstream/171692; ENST00000431501/Downstream/81457;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/174641, chr7-CpG: 25/Downstream/517014
Upstream sequence
gaagattgaagggcaaggagagattggggttcagttttagaaatgttcagtttagatgctgagagcacatccaagcagtgacgttaagtgcacagatgAG
Downstream sequence
AATTATAAAAGATGAAAAGTAATTTAAAATAAGACTTTCTTCTTCATGGGGGGAAACGCCATTTAACATATAAGAGTATATCAAGTTTTATAACTTTAAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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