AKAP9 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004692
Fusion event
HBV-AKAP9 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2746
Orient
-
Integrated sequence
GGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTA| |TTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAG
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
91671908/92042594 (Hg38)
End
91671908/92042594 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA7E
Target gene
AKAP9
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-10525/Upstream/16127325; hsa-mir-10399/Downstream/161421;
Nearest TSS
ENST00000635602/Upstream/1890; ENST00000491695/Downstream/15032;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/101560, chr7-CpG: 115/Downstream/91187
Nearest cancer related gene
AKAP9(OG, No orient, 0)
Upstream sequence
attgagaagaagattgaagggcaaggagagattggggttcagttttagaaatgttcagtttagatgctgagagcacatccaagcagtgacgttaagtgca
Downstream sequence
ATGACATGCTGTTTCCAAGTTGACAGGTTTTCTTTCTGTCTTCTCCTCTCTTCCTTTACACAAACTTAAACAGAATGGAAATGAAAACCAAGGAGAAGTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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