Basic Information
VIS ID
TVIS10004693
Fusion event
HBV-chr7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2686
Orient
-
Integrated sequence
AATATGTGGGCCCTCTTACAGTTAATGAAAAAAGGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGATAA| |AGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGA
Host Sequence
Chromosome
chr7
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
131464629/131779870 (Hg38)
End
131464629/131779870 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7H
Nearest miRNA
hsa-mir-10525/Upstream/902331; hsa-mir-10399/Downstream/1254990;
Nearest TSS
ENST00000635602/Upstream/221653; ENST00000452219/Downstream/117771;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/221623, chr7-CpG: 35/Downstream/165545
Upstream sequence
acctgtagtcccagctactcaggaggctgaggcaggagaatcgcttgaacccacgaggcagaggttttagtgagccgagattacaccactgcactccagc
Downstream sequence
ttgtgggtgtgtggtgctatttaattttaatttgcatttctttgatgactaatgatatcgagcatctttaaatttgtttattgcctatccatatattttc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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