DENND1B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004701
Fusion event
HBV-DENND1B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1825
Orient
-
Integrated sequence
AGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAAT
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
197486025/197516895 (Hg38)
End
197486025/197516895 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA1K
Target gene
DENND1B
miRNAs that regulate target gene
hsa-mir-6869-5p ; hsa-mir-155-5p ; hsa-mir-4312 ; hsa-mir-532-5p ; hsa-mir-802 ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-195-3p
Nearest miRNA
hsa-mir-101-1/Upstream/934414; hsa-mir-1182/Downstream/1341978;
Nearest TSS
ENST00000473358/Upstream/69426; ENST00000440885/Downstream/29878;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/315306, chr1-CpG: 103/Downstream/257906
Upstream sequence
ATATTAACTATGCAGGACCTGAAATGTAAATGACTATGATAGAGAAAAATAATCTGAACCCACACaataaaaataaaaaatatatacattattttaaCAC
Downstream sequence
AATTGGGTATAGTGacttatccttcaacatccagctcaaatgtagcctctggaaagctttatctgctaagtgttcctctgtatggccacatatttggtaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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