Basic Information
VIS ID
TVIS10004703
Fusion event
HBV-PROSER2-AS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1954
Orient
-
Integrated sequence
TCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTT| |TTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACC
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh37/hg19
Start
11916537/11874538 (Hg38)
End
11916537/11874538 (Hg38)
Orient
-
Location type
Intron
Target gene
PROSER2-AS1
Nearest miRNA
hsa-mir-3155a/Upstream/5722261; hsa-mir-107/Downstream/256222;
Nearest TSS
ENST00000439456/Upstream/4894; ENST00000437298/Downstream/257;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/4105, chr10-CpG: 63/Downstream/19714
Upstream sequence
GCACTGTTTCTCTGCGTGTATTTATCGCTGTGACGTGGCGAGATTAATAAACTTGTTTTCCCCTAAACTGCTTCCCTGAGTTCTTAAACTTCTGTCATCA
Downstream sequence
AAGAATGGTGAACTCTGAGGGAGCAGTCGCCTTGTTTTCCTGTTTCTTCTCATCTTGCTGTGGTCCCCGCCAGGGCTGCTGgggggaggaggagggggag
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate