Basic Information
VIS ID
TVIS10004706
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1825
Orient
+
Integrated sequence
AGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAAT
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
1660532/1639302 (Hg38)
End
1660532/1639302 (Hg38)
Orient
-
Location type
Intron
Nearest miRNA
hsa-mir-210/Upstream/382632; hsa-let-7a-2/Downstream/220162;
Nearest TSS
ENST00000527297/Upstream/9527; ENST00000538190/Downstream/24041;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/64389, chr11-CpG: 29/Downstream/13302
Nearby gene
KRTAP5-5(-8372) ;
Upstream sequence
CCCATAATTAGGTTTTCCTGCAAATGTGCACGTTCATATCTAAAGCGAAATCACATCTCTATTCGGCACCATGCCAGGGGCGGAAGGCGCCTGCTCTCTA
Downstream sequence
AGACAATGGTTTTATAGTAACGATTGCAGCCTCCACCCAGAGAGCTTCAGGGGCCTGAGCTAGGGGCTGTGCTGAGGAGGGGGCTCCGGTCACCTGCGGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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