Basic Information
VIS ID
TVIS10004710
Fusion event
HBV-THAP12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3086
Orient
-
Integrated sequence
CCAACAAGGATCACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCATTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTGGGGTGGAGCCCTCA| |GGCTCAGGGCATATTGACAACAGTGCCAGCAGCGCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTCTCCACCTCTAAGA
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76084524/76373480 (Hg38)
End
76084524/76373480 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA11H
Target gene
THAP12
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-98-5p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-10392/Upstream/1038294; hsa-let-7a-2/Downstream/3028542;
Nearest TSS
ENST00000527297/Upstream/4837; ENST00000530460/Downstream/7462;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/51277, chr11-CpG: 103/Downstream/7000
Upstream sequence
ACAACTCACCCCATTGTTTGGAAGATTAAATGAGTTGATATGAAAGTACTTCAggctgggcgtggtgtctcacatctgcaatcctaagactttgggaggc
Downstream sequence
tgaacaaggggggaatgcttcagctcaggagtccaagaccagcctgggcaacatggtgagaccctgtctctaaaaaaaatttttttcaaaaattagccgg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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