Basic Information
VIS ID
TVIS10004718
Fusion event
HBV-LOC107984844 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2055
Orient
-
Integrated sequence
TGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCA| |TACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTA
Host Sequence
Chromosome
chr16
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
18947830/18936508 (Hg38)
End
18947830/18936508 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107984844
Nearest miRNA
hsa-mir-1225/Upstream/441932; hsa-mir-11401/Downstream/2569541;
Nearest TSS
ENST00000527434/Upstream/9645; ENST00000561963/Downstream/47426;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/9704, chr16-CpG: 44/Downstream/47326
Upstream sequence
ttctcctgcctcagcctccagagtagctgggattacaggtgcacaccaccatgcctggctaatttttgtattttcaatagagatggggtttcaccatatt
Downstream sequence
ggccaggctggtctgaaactcatctcacgtgatctgcccacctcagcctcccaaattgctgggattacaggcgtgagccaccgcacctggccaatttttg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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