Basic Information
VIS ID
TVIS10004720
Fusion event
HBV-TRAPPC8 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2104
Orient
-
Integrated sequence
TGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTG| |GCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGT
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
29478690/31898727 (Hg38)
End
29478690/31898727 (Hg38)
Orient
+
Location type
Intron
Target gene
TRAPPC8
miRNAs that regulate target gene
hsa-mir-607 ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-548o-3p ; hsa-mir-1323
Nearest miRNA
hsa-mir-1-2/Upstream/1599767; hsa-mir-122/Downstream/3693010;
Nearest TSS
ENST00000575820/Upstream/7520; ENST00000580420/Downstream/40735;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/174436, chr18-CpG: 95/Downstream/43711
Junction sequence
AATC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate