Basic Information
VIS ID
TVIS10004721
Fusion event
HBV-TRAPPC8 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1807
Orient
+
Integrated sequence
TCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
29478717/31898754 (Hg38)
End
29478717/31898754 (Hg38)
Orient
-
Location type
Intron
Target gene
TRAPPC8
miRNAs that regulate target gene
hsa-mir-607 ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-548o-3p ; hsa-mir-1323
Nearest miRNA
hsa-mir-1-2/Upstream/1599794; hsa-mir-122/Downstream/3692983;
Nearest TSS
ENST00000575820/Upstream/7547; ENST00000580420/Downstream/40708;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/174463, chr18-CpG: 95/Downstream/43684
Upstream sequence
TACAGCCAGCGTTGTCTGATTGATTCCTGATCCAATTTTAGTTTTTTTTGTAAAAACATAATCAGTTGATTTTGTGGACTACTACATCAGTAATCTAGAA
Downstream sequence
TTAGATTATCCATTTTAGAAAAGAATAAAAACAAATGAAAACATTCTTACTATGAAATTACAAGATGGAATCCTATTGCTGGCAAACAGCAGCAAAAGTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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